Our studies reveal the polymodal nature of itch sensory neurons and identify a role for PIEZO1 in the sensation of itch.ĭiscrete subsets of somatosensory neurons within the dorsal root ganglion (DRG) and trigeminal ganglion selectively drive itch behaviours in mice 5, 6. Finally, mice expressing a gain-of-function Piezo1 allele 4 exhibit enhanced mechanical itch behaviours. Loss of PIEZO1 function in peripheral neurons greatly reduces mechanically evoked scratching behaviours and both acute and chronic itch-evoked sensitization. 3) is selectively expressed by itch-specific sensory neurons and is required for their mechanically activated currents. Here we show that the mechanically activated ion channel PIEZO1 (ref. In contrast to chemical itch pathways, which have been extensively studied, the mechanisms that underlie the transduction of mechanical itch are largely unknown. Mechanical itch can be triggered by light sensations such as wool fibres or a crawling insect 2. Chemical itch is triggered by many endogenous and exogenous cues, such as pro-inflammatory histamine, which is released during an allergic reaction 1. Itch triggers scratching, a behavioural defence mechanism that aids in the removal of harmful irritants and parasites 1. “Our expanded GDi service program will give independent garages the support they need to capitalize on this fast-growing market.”įor more on Delphi Technologies’ GDi program visit or. That is where the support of an original equipment manufacturer can give garages a competitive advantage,” adds Tibbert. “As an OE supplier, we understand the challenges of maintaining and repairing these highly advanced, high-pressure systems. Delphi Technologies’ GDi full-service solution will enable garages to quickly and efficiently provide high-quality service for this new technology. Fitted as OE to more than 3 million vehicles, this GDi technology has begun to enter the aftermarket with owners seeking high-quality independent repairs. The Multec 14 (M14) 350-bar pressure injection system, launched in 2017, increased injection pressure from the industry norm of 200 bar to 350 bar to help automakers meet both Euro 6d and China 6 emissions standards. With the Hartridge Excalibur GDi Master, aftermarket customers can differentiate themselves from the local competition with a fast return on investment in this easy market entry for new workshops. The Excalibur GDi Master is a plug-and-play test bench capable of powerful flow and high frequency injection rates that allow it to test coil and piezo injectors of both GDi and PFI technology types in as little as five minutes. The growing GDi injector market introduces new and fast-changing technologies for which Hartridge and Delphi Technologies can provide cutting-edge test solutions to the workshop. GDi testing in as little as five minutes with Hartridge “Building on our pioneering OE expertise, our GDi solution provides technicians with everything they need to perform premium end-to-end service with access to leading all-makes diagnostics and test solutions that can increase vehicle uptime and garage profitability over 30%.” “The GDi equipped new vehicle market is expected to grow by more than 10 percent annually through 2026, which presents an exciting opportunity for the aftermarket,” said James Tibbert, EMEA marketing director, Delphi Technologies Aftermarket. By expanding its product offering to more than 3 million Hyundai and Kia models, the company increases its total number of premium end-to-end service opportunities by more than 75 percent for its aftermarket customers. Along with its pioneering GDi product portfolio, the aftermarket solution features comprehensive training, advanced diagnostics, testing and cleaning equipment, technical service, cataloging and market data. Its comprehensive GDi solution already consists of pumps, injectors and service kits fitted as OE to more than 3.9 million popular PSA vehicles. Profitable end-to-end service opportunities for a growing marketĪs a leading manufacturer of OE GDi technology with 30 percent market share worldwide, Delphi Technologies extends its pioneering OE expertise to the aftermarket.
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